3zn3

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Template:STRUCTURE 3zn3

Contents

N-terminal domain of S. pombe Cdc23 APC subunit

Template:ABSTRACT PUBMED 23583778

Function

[APC8_SCHPO] Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.[1]

About this Structure

3zn3 is a 1 chain structure with sequence from Cbs 356. Full crystallographic information is available from OCA.

Reference

  • Zhang Z, Chang L, Yang J, Conin N, Kulkarni K, Barford D. The Four Canonical TPR Subunits of Human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelix. J Mol Biol. 2013 Apr 11. pii: S0022-2836(13)00233-7. doi:, 10.1016/j.jmb.2013.04.004. PMID:23583778 doi:http://dx.doi.org/10.1016/j.jmb.2013.04.004
  1. ↑ Yamashita YM, Nakaseko Y, Kumada K, Nakagawa T, Yanagida M. Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses. Genes Cells. 1999 Aug;4(8):445-63. PMID:10526233

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