4ldc
From Proteopedia
Contents |
Crystal Structure of DOC2B C2B domain
Template:ABSTRACT PUBMED 23994332
Function
[DOC2B_RAT] Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.[1] [2]
About this Structure
4ldc is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
Reference
- Giladi M, Michaely L, Almagor L, Bar-On D, Buki T, Ashery U, Khananshvili D, Hirsch JA. The C2B Domain Is the Primary Ca Sensor in DOC2B: A Structural and Functional Analysis. J Mol Biol. 2013 Aug 28. pii: S0022-2836(13)00537-8. doi:, 10.1016/j.jmb.2013.08.017. PMID:23994332 doi:10.1016/j.jmb.2013.08.017
- ↑ Friedrich R, Groffen AJ, Connell E, van Weering JR, Gutman O, Henis YI, Davletov B, Ashery U. DOC2B acts as a calcium switch and enhances vesicle fusion. J Neurosci. 2008 Jul 2;28(27):6794-806. doi: 10.1523/JNEUROSCI.0538-08.2008. PMID:18596155 doi:10.1523/JNEUROSCI.0538-08.2008
- ↑ Groffen AJ, Martens S, Diez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M. Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science. 2010 Mar 26;327(5973):1614-8. doi: 10.1126/science.1183765. Epub 2010, Feb 11. PMID:20150444 doi:10.1126/science.1183765
