4c0j

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Template:STRUCTURE 4c0j

Contents 1 Crystal structure of Drosophila Miro EF hand and cGTPase domains in the apo state (Apo-MiroS) 2 Function 3 About this Structure 4 Reference

Crystal structure of Drosophila Miro EF hand and cGTPase domains in the apo state (Apo-MiroS)

Template:ABSTRACT PUBMED 24071720

Function

[MIRO_DROME] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).^{[1] [2]}

About this Structure

4c0j is a 1 chain structure with sequence from Drome. Full crystallographic information is available from OCA.

Reference

• Klosowiak JL, Focia PJ, Chakravarthy S, Landahl EC, Freymann DM, Rice SE. Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro. EMBO Rep. 2013 Sep 27. doi: 10.1038/embor.2013.151. PMID:24071720 doi:http://dx.doi.org/10.1038/embor.2013.151

1. ↑ Guo X, Macleod GT, Wellington A, Hu F, Panchumarthi S, Schoenfield M, Marin L, Charlton MP, Atwood HL, Zinsmaier KE. The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. Neuron. 2005 Aug 4;47(3):379-93. PMID:16055062 doi:http://dx.doi.org/10.1016/j.neuron.2005.06.027
2. ↑ Glater EE, Megeath LJ, Stowers RS, Schwarz TL. Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent. J Cell Biol. 2006 May 22;173(4):545-57. PMID:16717129 doi:http://dx.doi.org/jcb.200601067