4blu

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Template:STRUCTURE 4blu

Contents

Crystal structure of Escherichia coli 23S rRNA (A2030-N6)- methyltransferase RlmJ

Template:ABSTRACT PUBMED 23945937

Function

[RLMJ_ECOLI] Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Seems to be required for the utilization of extracellular DNA as the sole source of carbon and energy.[1] [2]

About this Structure

4blu is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

Reference

  • Punekar AS, Liljeruhm J, Shepherd TR, Forster AC, Selmer M. Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ. Nucleic Acids Res. 2013 Aug 13. PMID:23945937 doi:10.1093/nar/gkt719
  1. ↑ Palchevskiy V, Finkel SE. Escherichia coli competence gene homologs are essential for competitive fitness and the use of DNA as a nutrient. J Bacteriol. 2006 Jun;188(11):3902-10. PMID:16707682 doi:10.1128/JB.01974-05
  2. ↑ Golovina AY, Dzama MM, Osterman IA, Sergiev PV, Serebryakova MV, Bogdanov AA, Dontsova OA. The last rRNA methyltransferase of E. coli revealed: the yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA. RNA. 2012 Sep;18(9):1725-34. doi: 10.1261/rna.034207.112. Epub 2012 Jul 30. PMID:22847818 doi:10.1261/rna.034207.112

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