4a5u

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Template:STRUCTURE 4a5u

Contents

Turnip yellow mosaic virus proteinase and Escherichia coli 30S ribosomal S15

Template:ABSTRACT PUBMED 23966860

Function

[POLR_TYMV] Acts as a cysteine protease, methyltransferase and deubiquitinase. The cyteine protease activity cleaves the polyprotein giving rise to mature proteins. The methyltransferase domain is probably involved in viral RNA capping. The deubiquitylating activity counteracts the degradation of the viral polymerase mediated by the host ubiquitin-proteasome system. The polymerase is thus stabilized and infectivity is increased.[1] RNA-directed RNA polymerase is responsible for the replication and transcription of the genome.[2] [E8Y371_ECOKO] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity).[HAMAP-Rule:MF_01343] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA (By similarity).[HAMAP-Rule:MF_01343]

About this Structure

4a5u is a 2 chain structure with sequence from Escherichia coli and Tymv. Full crystallographic information is available from OCA.

See Also

Reference

  • Lombardi C, Ayach M, Beaurepaire L, Chenon M, Andreani J, Guerois R, Jupin I, Bressanelli S. A compact viral processing proteinase/ubiquitin hydrolase from the OTU family. PLoS Pathog. 2013 Aug;9(8):e1003560. doi: 10.1371/journal.ppat.1003560. Epub 2013, Aug 15. PMID:23966860 doi:http://dx.doi.org/10.1371/journal.ppat.1003560
  1. ↑ Chenon M, Camborde L, Cheminant S, Jupin I. A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity. EMBO J. 2012 Feb 1;31(3):741-53. doi: 10.1038/emboj.2011.424. Epub 2011 Nov 25. PMID:22117220 doi:http://dx.doi.org/10.1038/emboj.2011.424
  2. ↑ Chenon M, Camborde L, Cheminant S, Jupin I. A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity. EMBO J. 2012 Feb 1;31(3):741-53. doi: 10.1038/emboj.2011.424. Epub 2011 Nov 25. PMID:22117220 doi:http://dx.doi.org/10.1038/emboj.2011.424

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