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1w6j

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Template:STRUCTURE 1w6j

Contents

Structure of human OSC in complex with Ro 48-8071

Template:ABSTRACT PUBMED 15525992

Function

[ERG7_HUMAN] Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.[1]

About this Structure

1w6j is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. Nature. 2004 Nov 4;432(7013):118-22. PMID:15525992 doi:10.1038/nature02993
  1. ↑ Baker CH, Matsuda SP, Liu DR, Corey EJ. Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library. Biochem Biophys Res Commun. 1995 Aug 4;213(1):154-60. PMID:7639730 doi:http://dx.doi.org/S0006-291X(85)72110-9

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