4g4n
From Proteopedia
Contents |
MutM containing M77A mutation bound to undamaged DNA
Template:ABSTRACT PUBMED 23404556
Function
[P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
About this Structure
4g4n is a 3 chain structure with sequence from Atcc 12980. Full crystallographic information is available from OCA.
Reference
- Sung RJ, Zhang M, Qi Y, Verdine GL. Structural and biochemical analysis of DNA helix-invasion by the bacterial 8-oxoguanine DNA glycosylase MutM. J Biol Chem. 2013 Feb 12. PMID:23404556 doi:http://dx.doi.org/10.1074/jbc.M112.415612
