1usx

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Template:STRUCTURE 1usx

Contents 1 Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside

Template:ABSTRACT PUBMED 15016893

Function

[HN_NDVB] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).

About this Structure

1usx is a 3 chain structure with sequence from Avian paramyxovirus type 1. Full crystallographic information is available from OCA.

See Also

• Hemagglutinin

Reference

• Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G. Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion. J Virol. 2004 Apr;78(7):3733-41. PMID:15016893