2w0s

From Proteopedia

Revision as of 12:14, 20 November 2013 by OCA (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 2w0s

Contents

Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate

Template:ABSTRACT PUBMED 18971333

Function

[KTHY_VACCC] Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity).

About this Structure

2w0s is a 2 chain structure with sequence from Vaccc. Full crystallographic information is available from OCA.

See Also

Reference

  • Caillat C, Topalis D, Agrofoglio LA, Pochet S, Balzarini J, Deville-Bonne D, Meyer P. Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16900-5. Epub 2008 Oct 29. PMID:18971333

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w0s"
Personal tools