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2w0s
From Proteopedia
Contents |
Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate
Template:ABSTRACT PUBMED 18971333
Function
[KTHY_VACCC] Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity).
About this Structure
2w0s is a 2 chain structure with sequence from Vaccc. Full crystallographic information is available from OCA.
See Also
Reference
- Caillat C, Topalis D, Agrofoglio LA, Pochet S, Balzarini J, Deville-Bonne D, Meyer P. Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16900-5. Epub 2008 Oct 29. PMID:18971333
