1xga
From Proteopedia
|
ALPHA CONOTOXIN GI: 2-7;3-13 (NATIVE) DISULFIDE BOND ISOMER, NMR, 35 STRUCTURES
Overview
The three possible disulfide bonded isomers of alpha-conotoxin GI have, been selectively synthesised and their structures determined by 1H NMR, spectroscopy. alpha-Conotoxin GI derives from the venom of Conus, geographus and is a useful neuropharmacological tool as it selectively, binds to the nicotinic acetylcholine receptor (nAChR), a ligand-gated ion, channel involved in nerve signal transmission. The peptide has the, sequence ECCNPACGRHYSC-NH2, and the three disulfide bonded isomers are, referred to as GI(2-7;3-13), GI(2-13;3-7) and GI(2-3;7-13). The NMR, structure for the native isomer GI(2-7;3-13) is of excellent quality, with, a backbone pairwise RMSD of 0.16 A for a family of 35 structures, and, comprises primarily a distorted 310 helix between residues 5 to 11. The, two ... [(full description)]
About this Structure
1XGA is a [Single protein] structure of sequence from [Conus geographus] with NH2 as [ligand]. Structure known Active Sites: BNG and STY. Full crystallographic information is available from [OCA].
Reference
Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability., Gehrmann J, Alewood PF, Craik DJ, J Mol Biol. 1998 May 1;278(2):401-15. PMID:9571060
Page seeded by OCA on Tue Oct 30 16:32:11 2007
