4bj3

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Template:STRUCTURE 4bj3

Contents

Integrin alpha2 I domain E318W-collagen complex

Template:ABSTRACT PUBMED 23922814

Function

[ITA2_HUMAN] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

About this Structure

4bj3 is a 5 chain structure. Full crystallographic information is available from OCA.

Reference

  • Carafoli F, Hamaia SW, Bihan D, Hohenester E, Farndale RW. An activating mutation reveals a second binding mode of the integrin alpha2 I domain to the GFOGER motif in collagens. PLoS One. 2013 Jul 29;8(7):e69833. doi: 10.1371/journal.pone.0069833. Print 2013. PMID:23922814 doi:http://dx.doi.org/10.1371/journal.pone.0069833

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