4kop
From Proteopedia
Contents |
Crystal Structure of WHY2 from Arabidopsis thaliana
Template:ABSTRACT PUBMED 24192350
Function
[WHY2_ARATH] Single-stranded DNA-binding protein that associates with mitochondrial DNA and may play a role in the regulation of the gene expression machinery. Seems also to be required to prevent break-induced DNA rearrangements in the mitochondrial genome. Can bind to melt double-stranded DNA in vivo.[1] [2] [3]
About this Structure
4kop is a 4 chain structure with sequence from Arath. Full crystallographic information is available from OCA.
Reference
- Cappadocia L, Parent JS, Sygusch J, Brisson N. A family portrait: structural comparison of the Whirly proteins from Arabidopsis thaliana and Solanum tuberosum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1207-11., doi: 10.1107/S1744309113028698. Epub 2013 Oct 26. PMID:24192350 doi:http://dx.doi.org/10.1107/S1744309113028698
- ↑ Marechal A, Parent JS, Sabar M, Veronneau-Lafortune F, Abou-Rached C, Brisson N. Overexpression of mtDNA-associated AtWhy2 compromises mitochondrial function. BMC Plant Biol. 2008 Apr 18;8:42. doi: 10.1186/1471-2229-8-42. PMID:18423020 doi:http://dx.doi.org/10.1186/1471-2229-8-42
- ↑ Cappadocia L, Marechal A, Parent JS, Lepage E, Sygusch J, Brisson N. Crystal structures of DNA-Whirly complexes and their role in Arabidopsis organelle genome repair. Plant Cell. 2010 Jun;22(6):1849-67. Epub 2010 Jun 15. PMID:20551348 doi:10.1105/tpc.109.071399
- ↑ Janicka S, Kuhn K, Le Ret M, Bonnard G, Imbault P, Augustyniak H, Gualberto JM. A RAD52-like single-stranded DNA binding protein affects mitochondrial DNA repair by recombination. Plant J. 2012 Nov;72(3):423-35. doi: 10.1111/j.1365-313X.2012.05097.x. Epub 2012 , Aug 30. PMID:22762281 doi:http://dx.doi.org/10.1111/j.1365-313X.2012.05097.x
