4c8t

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Template:STRUCTURE 4c8t

Contents 1 Xenopus ZNRF3 ectodomain crystal form I 2 Function 3 About this Structure 4 Reference

Xenopus ZNRF3 ectodomain crystal form I

Template:ABSTRACT PUBMED 24225776

Function

[ZNRF3_XENTR] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity).

About this Structure

4c8t is a 2 chain structure with sequence from Silurana (xenopus) tropicalis. Full crystallographic information is available from OCA.

Reference

• Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY. Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776 doi:http://dx.doi.org/10.1038/ncomms3787