SAGA-associated factor (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes. SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation. SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.
3D structures of SAGA-associated factor
SGF11
2lo2 – ySGF zinc finger domain – yeast – NMR
[3kik]], 3kjl – ySGF Sus1-binding domain + Sus1
3mhh, 3m99, 4fip, 4fjc, 4fk5 – yUBP8 + Sus1 +SGF73 - yeast
3mhs – yUBP8 + Sus1 +SGF73 + ubiquitin
SGF29
3me9, 3mea, 3met, 3meu, 3mev, 3mew, 3mp1, 3mp6 – hSGF tudor domain + histone H3 peptide – human
3lx7, 3mp8 - hSGF tudor domain
SGF73
2lo3 – ySGF zinc finger domain – NMR
