We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1yso

From Proteopedia

Revision as of 14:28, 30 October 2007 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1yso.gif

1yso, resolution 1.73Å

Drag the structure with the mouse to rotate

YEAST CU, ZN SUPEROXIDE DISMUTASE WITH THE REDUCED BRIDGE BROKEN

Overview

The three-dimensional structure of yeast copper-zinc superoxide dismutase, (CuZnSOD) has been determined in a new crystal form in space group R32 and, refined against X-ray diffraction data using difference Fourier and, restrained crystallographic refinement techniques. The unexpected result, is that the copper ion has moved approximately 1 angstrom from its, position in previously reported CuZnSOD models, the copper-imidazolate, bridge is broken, and a roughly trigonal planar ligand geometry, characteristic of Cu(I) rather than Cu(II) is revealed. Final R values for, the two nearly identical room temperature structures are 18.6% for all 19, 149 reflections in the 10.0-1.7 angstrom resolution range and 18. 2% for, 17 682 reflections (F > 2 sigma) in the 10.0-1.73 angstrom resolution, ... [(full description)]

About this Structure

1YSO is a [Single protein] structure of sequence from [Candida albicans] with CU1 and ZN as [ligands]. Active as [Superoxide dismutase], with EC number [1.15.1.1]. Structure known Active Sites: CU and ZN. Full crystallographic information is available from [OCA].

Reference

Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase., Ogihara NL, Parge HE, Hart PJ, Weiss MS, Goto JJ, Crane BR, Tsang J, Slater K, Roe JA, Valentine JS, Eisenberg D, Tainer JA, Biochemistry. 1996 Feb 20;35(7):2316-21. PMID:8652572

Page seeded by OCA on Tue Oct 30 16:33:30 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yso"
Personal tools