Catabolite control protein (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.
3D structures of catabolite control protein
Updated on 02-December-2013
2jcg, 2hsg - BmCcpA – Bacillus megaterium
1sxg, 1sxh, 1sxi – BmCcpA (mutant)
2o20 - CcpA (mutant) – Streptococcus lactis
CcpA binary complex
2oen - BmCcpA + phosphocarrier protein HPr
2fep - BsCcpA + phosphocarrier protein HPr – Bacillus subtilis
CcpA ternary complex
1rzr – BmCcpA + phosphocarrier protein HPr + DNA
2nzu - BmCcpA + phosphocarrier protein HPr + glucose-6-phosphate
2nzv - BmCcpA + phosphocarrier protein HPr + fructose-1,6-diphosphate
1zvv – BsCcpA + catabolite repression Crh + DNA
3oqm, 3oqn, 3oqo - BsCcpA + phosphocarrier protein HPr + DNA
