Casein kinase
From Proteopedia
Casein kinase (CK) is a protein kinase which functions as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one.
3D Structures of casein kinase
Updated on 04-December-2013
CK1
2c47 – hCK1-γ2 – human
2chl - hCK1-γ3
2cmw – hCK1-γ1 + inhibitor
2izr, 2izs, 2izs, 2izu, 2izt - hCK1-γ3 + inhibitor
1cki – rCK1-δ (mutant) – rat
1ckj - rCK1-δ (mutant) + WO4
1csn – yCK1 + MgATP – fission yeast
2csn, 1eh4 – yCK1 catalytic domain + inhibitor
CK2 catalytic subunit
1na7, 3fwq, 3juh - hCK2 α subunit (mutant)
3ofm - hCK2 α’ subunit
2r7i - rCK2 α subunit
1lpu, 1lr4, 1jam - mCK2 α subunit
CK2 catalytic subunit binary complex
2pvr - hCK2 α subunit + sulfate
3rp0 – hCK2 α subunit + α’ subunit + ATP analog
3bqc, 3c13 - hCK2 α subunit + emodin
1j91 - mCK2 α subunit + ATP competitive inhibitor - maize
1lp4 - mCK2 α subunit + Mg-AMPPNP
3nsz - hCK2 α subunit + AMPPN
1m2p, 1m2q, 1m2r, 1om1, 2oxd, 2oxx, 2oxy, 2qc6, 2pvh, 3fl5, 3kxg, 3kxh, 3kxm, 3kxn, 3pvg, 3pwd - mCK2 α subunit + inhibitor
3e3b, 2zjw, 3h30, 3mb6, 3mb7, 3nga, 3rps, 3pe1, 3pe2, 3amy, 3at3, 3at4 - hCK2 α subunit + inhibitor
2pvh, 2pvj, 2pvk, 2pvl, 2pvm, 2pvn, 3be9 - mCK2 α subunit (mutant) + inhibitor
CK2 regulatory subunit
2r6m - rCK2 β subunit
1rqf - CK2 β subunit + cyclin-dependent kinase peptide – Xenopus laevis
CK2 catalytic + regulatory subunits
1jwh - hCK2 α subunit + β subunit
1ds5 - mCK2 α subunit + β subunit peptide
