Sandbox Reserved 769

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This Sandbox is Reserved from Sep 25, 2013, through Mar 31, 2014 for use in the course "BCH455/555 Proteins and Molecular Mechanisms" taught by Michael B. Goshe at the North Carolina State University. This reservation includes Sandbox Reserved 299, Sandbox Reserved 300 and Sandbox Reserved 760 through Sandbox Reserved 779.

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spinqualitylabelsall models Structure of a tryptophan synthase quinonoid intermediate. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Tryptophan Synthase

Tryptophan synthase is a classic enzyme that channels a metabolic intermediate, indole

Contents 1 Tryptophan Synthase 2 General Information 3 Structure 4 Enzymatic Mechanism 5 References

General Information

Gene Name: trpA, trpB^[1]

Organism: Salmonella typhimurium (strain LT2) ^[1]

Classification: Lyase ^[2]

Length: trpA: 268 AA ^[1] trpB: 397 AA ^[1]

Molecular Weight: 72012.45 Da ^[3]

Isoelectric Point: 5.62 ^[4]

Chains: A, B ^[2]

Ligands: Sodium Ion ([1]), pyridoxal-5'-phosphate ([2])^[2]

Structure

Alpha Subunit

Beta Subunit

Enzymatic Mechanism

References

1. ↑ ^{1.0 1.1 1.2 1.3} http://www.uniprot.org/uniprot/P00929
2. ↑ ^{2.0 2.1 2.2} http://oca.weizmann.ac.il/oca-bin/ocashort
3. ↑ http://www.rcsb.org/pdb/explore.do?structureId=1QOP
4. ↑ http://mips.helmholtz-muenchen.de/genre/proj/FGDB/singleGeneReport.html?entry=FGSG_10743