Molecular Playground/Bacterial Chemotaxis Complex

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Ternary complex of the truncated receptor (gray), CheA (blue), and CheW (cyan) 3UR1

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One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst.

Bacterial chemotaxis is a method for cells to sense and adapt to chemicals in their environment. It is carried out by large arrays of membrane associated multi-protein complexes that form at the poles of the cells. The major players involved are the receptor, histidine kinase CheA, and adaptor protein CheW. Upon ligand binding to the receptor – be it attractant or repellant – a signal is relayed to CheA, which subsequently phosphorylates CheY

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Elizabeth R. Haglin, Maryam Kashefy, Michal Harel

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