4lrr

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Template:STRUCTURE 4lrr

Contents 1 Ternary complex between E. coli thymidylate synthase, dUMP, and F9 2 Function 3 About this Structure 4 Reference

Ternary complex between E. coli thymidylate synthase, dUMP, and F9

Template:ABSTRACT PUBMED 24147825

Function

[TYSY_ECO57] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

About this Structure

4lrr is a 1 chain structure with sequence from Eco57. Full crystallographic information is available from OCA.

Reference

• Ferrari S, Calo S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP. 2'-deoxyuridine-5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives. J Med Chem. 2013 Oct 22. PMID:24147825 doi:http://dx.doi.org/10.1021/jm4014086