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3wc8
From Proteopedia
Contents |
Dimeric horse cytochrome c obtained by refolding with desalting method
Template:ABSTRACT PUBMED 24206001
Function
[CYC_HORSE] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
About this Structure
3wc8 is a 1 chain structure with sequence from Equus caballus. Full crystallographic information is available from OCA.
Reference
- Parui PP, Deshpande MS, Nagao S, Kamikubo H, Komori H, Higuchi Y, Kataoka M, Hirota S. Formation of Oligomeric Cytochrome c during Folding by Intermolecular Hydrophobic Interaction between N- and C-Terminal alpha-Helices. Biochemistry. 2013 Dec 3;52(48):8732-44. doi: 10.1021/bi400986g. Epub 2013 Nov, 20. PMID:24206001 doi:http://dx.doi.org/10.1021/bi400986g
