4nk0

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Template:STRUCTURE 4nk0

Contents 1 Human histidine triad nucleotide-binding protein 2 (hHINT2) in P212121 space group at 2.02 A 2 Function 3 About this Structure 4 Reference

Human histidine triad nucleotide-binding protein 2 (hHINT2) in P212121 space group at 2.02 A

Function

[HINT2_HUMAN] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.^{[1] [2]}

About this Structure

4nk0 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

1. ↑ Martin J, Magnino F, Schmidt K, Piguet AC, Lee JS, Semela D, St-Pierre MV, Ziemiecki A, Cassio D, Brenner C, Thorgeirsson SS, Dufour JF. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Gastroenterology. 2006 Jun;130(7):2179-88. PMID:16762638 doi:10.1053/j.gastro.2006.03.024
2. ↑ Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Endocrinology. 2008 Nov;149(11):5461-9. doi: 10.1210/en.2008-0400. Epub 2008 Jul , 24. PMID:18653718 doi:10.1210/en.2008-0400