4lkf

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Template:STRUCTURE 4lkf

Contents

Crystal Structure of Pseudomonas aeruginosa Lectin LecA Complexed with GalA-WKY at 1.64 A Resolution

Template:ABSTRACT PUBMED 24307364

Function

[PA1L_PSEAE] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.

About this Structure

4lkf is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kadam RU, Bergmann M, Garg D, Gabrieli G, Stocker A, Darbre T, Reymond JL. Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA. Chemistry. 2013 Dec 9;19(50):17054-63. doi: 10.1002/chem.201302587. Epub 2013 Nov, 4. PMID:24307364 doi:http://dx.doi.org/10.1002/chem.201302587

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