4lr2

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Template:STRUCTURE 4lr2

Contents

Crystal Structure of Human ENPP4 (apo)

Template:ABSTRACT PUBMED 22995898

Function

[ENPP4_HUMAN] Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.[1]

About this Structure

4lr2 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120(22):4432-40. doi: 10.1182/blood-2012-04-425215. Epub 2012 , Sep 20. PMID:22995898 doi:http://dx.doi.org/10.1182/blood-2012-04-425215
  1. ↑ Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120(22):4432-40. doi: 10.1182/blood-2012-04-425215. Epub 2012 , Sep 20. PMID:22995898 doi:http://dx.doi.org/10.1182/blood-2012-04-425215

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