1usy

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Template:STRUCTURE 1usy

Contents

ATP phosphoribosyl transferase (HisG:HisZ) complex from Thermotoga maritima

Template:ABSTRACT PUBMED 15660995

Function

[HIS1_THEMA] Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). [HISZ_THEMA] Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).

About this Structure

1usy is a 8 chain structure with sequence from Thema. Full crystallographic information is available from OCA.

See Also

Reference

  • Vega MC, Zou P, Fernandez FJ, Murphy GE, Sterner R, Popov A, Wilmanns M. Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. Mol Microbiol. 2005 Feb;55(3):675-86. PMID:15660995 doi:http://dx.doi.org/10.1111/j.1365-2958.2004.04422.x

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