2kvb

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Template:STRUCTURE 2kvb

Contents

Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside

Template:ABSTRACT PUBMED 20615935

Function

[MPRI_BOVIN] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

About this Structure

2kvb is a 1 chain structure with sequence from Bovin. Full experimental information is available from OCA.

See Also

Reference

  • Olson LJ, Peterson FC, Castonguay A, Bohnsack RN, Kudo M, Gotschall RR, Canfield WM, Volkman BF, Dahms NM. Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12493-8. Epub 2010 Jun 30. PMID:20615935

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