4la5

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Template:STRUCTURE 4la5

Contents

Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2)

Template:ABSTRACT PUBMED 23844678

Function

[MIBS_STRCO] Catalyzes the cyclization of 2-methylgeranyl diphosphate (2-MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%).

About this Structure

4la5 is a 1 chain structure with sequence from Strco. Full crystallographic information is available from OCA.

Reference

  • Koksal M, Chou WK, Cane DE, Christianson DW. Unexpected Reactivity of 2-Fluorolinalyl Diphosphate in the Active Site of Crystalline 2-Methylisoborneol Synthase. Biochemistry. 2013 Jul 22. PMID:23844678 doi:10.1021/bi400797c

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