1b07

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Template:STRUCTURE 1b07

Contents

CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR

Template:ABSTRACT PUBMED 9851931

Function

[CRK_MOUSE] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

About this Structure

1b07 is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

See Also

Reference

  • Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA. Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science. 1998 Dec 11;282(5396):2088-92. PMID:9851931

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