4j2c

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Template:STRUCTURE 4j2c

Contents

GARP-SNARE Interaction

Template:ABSTRACT PUBMED 23932592

Function

[STX6_HUMAN] Involved in intracellular vesicle trafficking. [VPS51_HUMAN] Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.[1]

About this Structure

4j2c is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Abascal-Palacios G, Schindler C, Rojas AL, Bonifacino JS, Hierro A. Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6. Structure. 2013 Sep 3;21(9):1698-706. doi: 10.1016/j.str.2013.06.025. Epub 2013, Aug 8. PMID:23932592 doi:http://dx.doi.org/10.1016/j.str.2013.06.025
  1. ↑ Perez-Victoria FJ, Schindler C, Magadan JG, Mardones GA, Delevoye C, Romao M, Raposo G, Bonifacino JS. Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex. Mol Biol Cell. 2010 Oct 1;21(19):3386-95. doi: 10.1091/mbc.E10-05-0392. Epub 2010, Aug 4. PMID:20685960 doi:http://dx.doi.org/10.1091/mbc.E10-05-0392

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