4isk

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4isk

Contents 1 Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor 2 Function 3 About this Structure 4 Reference

Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor

Template:ABSTRACT PUBMED 23710599

Function

[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.

About this Structure

4isk is a 8 chain structure. Full crystallographic information is available from OCA.

Reference

• Tochowicz A, Dalziel S, Eidam O, O'Connell JD 3rd, Griner S, Finer-Moore JS, Stroud RM. Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta [g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells. J Med Chem. 2013 Jun 21. PMID:23710599 doi:http://dx.doi.org/10.1021/jm400490e