4lqk

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Template:STRUCTURE 4lqk

Structure of the vaccinia virus NF- B antagonist A46

Function

[A46_VACCW] Bcl-2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Targets several host TIR adapters including MYD88, TIRAP, TRIF and TICAM2 thereby blocking NF-kappa-B and TRIF-mediated IRF3 activation.

About this Structure

4lqk is a 4 chain structure. Full crystallographic information is available from OCA.

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