4nbk

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Template:STRUCTURE 4nbk

Contents

Tailoring Small Molecules for an Allosteric Site on Procaspase-6

Template:ABSTRACT PUBMED 24259468

Function

[CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

About this Structure

4nbk is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring Small Molecules for an Allosteric Site on Procaspase-6. ChemMedChem. 2013 Nov 20. doi: 10.1002/cmdc.201300424. PMID:24259468 doi:http://dx.doi.org/10.1002/cmdc.201300424

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