4l2x

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Template:STRUCTURE 4l2x

Contents

Crystal structure of human FPPS in complex with magnesium, CL02134, and inorganic pyrophosphate

Template:ABSTRACT PUBMED 23998921

Function

[FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

About this Structure

4l2x is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Leung CY, Park J, De Schutter JW, Sebag M, Berghuis AM, Tsantrizos YS. Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition. J Med Chem. 2013 Oct 3. PMID:23998921 doi:http://dx.doi.org/10.1021/jm400946f

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