2viu

From Proteopedia

Revision as of 16:56, 21 February 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2viu.gif

2viu, resolution 2.5Å

Drag the structure with the mouse to rotate

INFLUENZA VIRUS HEMAGGLUTININ

Overview

The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.

About this Structure

2VIU is a Single protein structure of sequence from Unidentified influenza virus with as ligand. Full crystallographic information is available from OCA.

Reference

Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077

Page seeded by OCA on Thu Feb 21 18:56:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2viu"
Personal tools