4lv4

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Template:STRUCTURE 4lv4

Contents 1 A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase 2 Function 3 About this Structure 4 Reference

A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase

Template:ABSTRACT PUBMED 24325645

Function

[ALF_MYCTU] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity).

About this Structure

4lv4 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Capodagli GC, Sedhom WG, Jackson M, Ahrendt KA, Pegan SD. A Noncompetitive Inhibitor for Mycobacterium tuberculosis's Class IIa Fructose 1,6-Bisphosphate Aldolase. Biochemistry. 2013 Dec 24. PMID:24325645 doi:http://dx.doi.org/10.1021/bi401022b