This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4itc
From Proteopedia
Contents |
Crystal Structure Analysis of the K1 Cleaved Adhesin domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis W83
Template:ABSTRACT PUBMED 24265933
Function
[KGP83_PORGN] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]
About this Structure
4itc is a 1 chain structure with sequence from Atcc 33277. Full crystallographic information is available from OCA.
Reference
- Ganuelas LA, Li N, Yun P, Hunter N, Collyer CA. The lysine gingipain adhesin domains from Porphyromonas gingivalis interact with erythrocytes and albumin: Structures correlate to function. Eur J Microbiol Immunol (Bp). 2013 Sep;3(3):152-62. doi:, 10.1556/EuJMI.3.2013.3.2. Epub 2013 Sep 23. PMID:24265933 doi:http://dx.doi.org/10.1556/EuJMI.3.2013.3.2
