4j14

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Template:STRUCTURE 4j14

Contents

Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound

Template:ABSTRACT PUBMED 23604141

Function

[CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.

About this Structure

4j14 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Mast N, Zheng W, Stout CD, Pikuleva IA. Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1. Mol Pharmacol. 2013 Jul;84(1):86-94. doi: 10.1124/mol.113.085902. Epub 2013 Apr, 19. PMID:23604141 doi:http://dx.doi.org/10.1124/mol.113.085902

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