4ikc
From Proteopedia
Contents |
Crystal Structure of catalytic domain of PTPRQ
Template:ABSTRACT PUBMED 23897475
Disease
[PTPRQ_HUMAN] Autosomal recessive nonsyndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry.
Function
[PTPRQ_HUMAN] Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.[1]
About this Structure
4ikc is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Yu KR, Kim YJ, Jung SK, Ku B, Park H, Cho SY, Jung H, Chung SJ, Bae KH, Lee SC, Kim BY, Erikson RL, Ryu SE, Kim SJ. Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1522-9. doi:, 10.1107/S0907444913010457. Epub 2013 Jul 19. PMID:23897475 doi:http://dx.doi.org/10.1107/S0907444913010457
- ↑ Jung H, Kim WK, Kim do H, Cho YS, Kim SJ, Park SG, Park BC, Lim HM, Bae KH, Lee SC. Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells. Biochem Biophys Res Commun. 2009 May 29;383(2):252-7. doi:, 10.1016/j.bbrc.2009.04.001. Epub 2009 Apr 5. PMID:19351528 doi:10.1016/j.bbrc.2009.04.001
