3ale

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Template:STRUCTURE 3ale

Contents

A type III polyketide synthase that produces diarylheptanoid

Template:ABSTRACT PUBMED 21041675

Function

[CUS_ORYSJ] Plant-specific type III polyketide synthase (PKS) that catalyzes the one-pot formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin by the condensation of two molecules of 4-coumaroyl-CoA and one molecule of malonyl-CoA.[1]

About this Structure

3ale is a 4 chain structure with sequence from Japanese rice. Full crystallographic information is available from OCA.

Reference

  • Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I. Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19778-83. Epub 2010 Nov 1. PMID:21041675 doi:http://dx.doi.org/10.1073/pnas.1011499107
  1. ↑ Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I. Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19778-83. Epub 2010 Nov 1. PMID:21041675 doi:http://dx.doi.org/10.1073/pnas.1011499107

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