3a8h

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Template:STRUCTURE 3a8h

Contents

Crystal structure of Nitrile Hydratase mutant S113A complexed with Trimethylacetamide

Template:ABSTRACT PUBMED 20221653

Function

[NHAA_RHOER] NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class. [NHAB_RHOER] NHase catalyzes the hydration of various nitrile compounds to the corresponding amides.

About this Structure

3a8h is a 2 chain structure with sequence from "mycobacterium_erythropolis"_gray_and_thornton_1928 "mycobacterium erythropolis" gray and thornton 1928. Full crystallographic information is available from OCA.

Reference

  • Yamanaka Y, Hashimoto K, Ohtaki A, Noguchi K, Yohda M, Odaka M. Kinetic and structural studies on roles of the serine ligand and a strictly conserved tyrosine residue in nitrile hydratase. J Biol Inorg Chem. 2010 Mar 10. PMID:20221653 doi:10.1007/s00775-010-0632-3

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