4k34

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Template:STRUCTURE 4k34

Contents 1 Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation 2 Function 3 About this Structure 4 Reference

Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation

Template:ABSTRACT PUBMED 24099674

Function

[CUSC_ECOLI] Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis.^{[1] [2]}

About this Structure

4k34 is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

Reference

• Lei HT, Bolla JR, Su CC, Yu EW. Crystal Structures of CusC Review Conformational Changes Accompanying Folding and Transmembrane Channel Formation. J Mol Biol. 2013 Oct 4. pii: S0022-2836(13)00626-8. doi:, 10.1016/j.jmb.2013.09.042. PMID:24099674 doi:http://dx.doi.org/10.1016/j.jmb.2013.09.042

1. ↑ Outten FW, Huffman DL, Hale JA, O'Halloran TV. The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli. J Biol Chem. 2001 Aug 17;276(33):30670-7. Epub 2001 Jun 8. PMID:11399769 doi:http://dx.doi.org/10.1074/jbc.M104122200
2. ↑ Franke S, Grass G, Rensing C, Nies DH. Molecular analysis of the copper-transporting efflux system CusCFBA of Escherichia coli. J Bacteriol. 2003 Jul;185(13):3804-12. PMID:12813074