4jcz

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Template:STRUCTURE 4jcz

Contents

Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis

Template:ABSTRACT PUBMED 24366866

Disease

[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

Function

[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

About this Structure

4jcz is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Niegowski D, Kleinschmidt T, Olsson U, Ahmad S, Rinaldo-Matthis A, Haeggstrom JZ. Crystal structures of Leukotriene C4 synthase in complex with product analogs, implications for the enzyme mechanism. J Biol Chem. 2013 Dec 23. PMID:24366866 doi:http://dx.doi.org/10.1074/jbc.M113.534628

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