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4l9i

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Revision as of 06:54, 22 January 2014 by OCA (Talk | contribs)
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Template:STRUCTURE 4l9i

Contents

Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine

Template:ABSTRACT PUBMED 24220010

Function

[RK_BOVIN] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity).

About this Structure

4l9i is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, Tesmer JJ. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol Pharmacol. 2014 Feb;85(2):237-48. doi: 10.1124/mol.113.089631. Epub 2013 Nov , 12. PMID:24220010 doi:http://dx.doi.org/10.1124/mol.113.089631

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OCA

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