4mdb

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Template:STRUCTURE 4mdb

Contents 1 Structure of Mos1 transposase catalytic domain and Raltegravir with Mg 2 Function 3 About this Structure 4 Reference

Structure of Mos1 transposase catalytic domain and Raltegravir with Mg

Template:ABSTRACT PUBMED 24397848

Function

[MOS1T_DROMA] Mediates transposition of transposon Mos1 by a 'cut and paste' mechanism. Transposases are sequence-specific nucleases and strand transferases that catalyze transposition through an ordered series of events: sequence-specific binding of transposase to the terminal inverted repeats (IR) present at each end of the transposon, pairing of the transposon IRs in a paired-end complex (PEC), cleavage of one or both DNA strands at each transposon end, capture of target DNA, and strand transfer to insert the transposon at a new site.

About this Structure

4mdb is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Wolkowicz UM, Morris ER, Robson M, Trubitsyna M, Richardson JM. Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir. ACS Chem Biol. 2014 Jan 10. PMID:24397848 doi:http://dx.doi.org/10.1021/cb400791u