4kfz

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Template:STRUCTURE 4kfz

Contents

Crystal structure of LMO2 and anti-LMO2 VH complex

Template:ABSTRACT PUBMED 24407558

Disease

[RBTN2_HUMAN] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.

Function

[RBTN2_HUMAN] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

About this Structure

4kfz is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Sewell H, Tanaka T, Omari KE, Mancini EJ, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts TH. Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Sci Rep. 2014 Jan 10;4:3643. doi: 10.1038/srep03643. PMID:24407558 doi:http://dx.doi.org/10.1038/srep03643

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