Adenosine kinase (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog. AdK deficiency causes hypermethioninemia.
3D structures of adenosine kinase
1lio – TgAdK – Toxoplasma gondii
2pkf – MtAdK – Mycobacterium tuberculosis
4n08 – TbAdK – Trypanosoma brucei
Adenosine kinase binary complex
1bx4 – hAdK + adenosine - human
2i6a, 2i6b – hAdK + prodrug
1dgm, 1lik – TgAdK + adenosine
2a9y – TgAdK (mutant) + dimethyladenosine
2abs – TgAdK (mutant) + AMP-PCP
2aa0 – TgAdK (mutant) + methylthiopurine
2pkk – MtAdK + fluoroadenosine
2pkn – MtAdK + AMP-PCP
2pkm – MtAdK + adenosine
3loo – AdK + adenosine tetraphosphate – Anopheles gambiae
2xtb – TbAdK + morpholine
Adenosine kinase ternary complex
1lii – TgAdK + adenosine + AMP-PCP
2a9z – TgAdK (mutant) + dimethyladenosine + AMP-PCP
1lij – TgAdK + prodrug + AMP-PCP
2ab8 – TgAdK (mutant) + methylthiopurine + AMP-PCP
3ubo – AdK + adenosine + ADP – Sinorhizobium meliloti
4dc3 – AdK + adenosine + fluoroadenosine – Schistosoma masoni
4n09 – TbAdK + adenosine + ADP
