3ai8

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Template:STRUCTURE 3ai8

Contents 1 Cathepsin B in complex with the nitroxoline 2 Function 3 About this Structure 4 See Also 5 Reference

Cathepsin B in complex with the nitroxoline

Function

[CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

About this Structure

3ai8 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

• Cathepsin

Reference

• Mirkovic B, Renko M, Turk S, Sosic I, Jevnikar Z, Obermajer N, Turk D, Gobec S, Kos J. Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds. ChemMedChem. 2011 May 20. doi: 10.1002/cmdc.201100098. PMID:21598397 doi:10.1002/cmdc.201100098