4f4w

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Template:STRUCTURE 4f4w

Contents 1 Y-family DNA polymerase chimera Dbh-Dpo4-Dpo4 #1 2 Function 3 About this Structure 4 See Also 5 Reference

Y-family DNA polymerase chimera Dbh-Dpo4-Dpo4 #1

Template:ABSTRACT PUBMED 23245850

Function

[DPO4_SULAC] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis (By similarity).

About this Structure

4f4w is a 6 chain structure with sequence from Sulac. Full crystallographic information is available from OCA.

See Also

• DNA polymerase

Reference

• Wilson RC, Jackson MA, Pata JD. Y-Family Polymerase Conformation Is a Major Determinant of Fidelity and Translesion Specificity. Structure. 2012 Dec 11. pii: S0969-2126(12)00420-0. doi:, 10.1016/j.str.2012.11.005. PMID:23245850 doi:http://dx.doi.org/10.1016/j.str.2012.11.005