2jgk

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Template:STRUCTURE 2jgk

Contents 1 Crystal structure of mouse acetylcholinesterase inhibited by aged fenamiphos 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of mouse acetylcholinesterase inhibited by aged fenamiphos

Template:ABSTRACT PUBMED 17402711

Function

[ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

About this Structure

2jgk is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

See Also

• Acetylcholinesterase

Reference

• Hornberg A, Tunemalm AK, Ekstrom F. Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state. Biochemistry. 2007 Apr 24;46(16):4815-25. Epub 2007 Apr 3. PMID:17402711 doi:http://dx.doi.org/10.1021/bi0621361