3w3z

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Template:STRUCTURE 3w3z

Contents

Crystal structure of Kap121p bound to RanGTP

Template:ABSTRACT PUBMED 23541588

Function

[IMB3_YEAST] Involved in the nuclear import of ribosomal proteins. Binds to nucleoporins and the GTP-bound form of GSP1 (Ran). Plays a role in protein secretion. [RAN_CANFA] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity).

About this Structure

3w3z is a 2 chain structure with sequence from Baker's yeast and Canfa. Full crystallographic information is available from OCA.

Reference

  • Kobayashi J, Matsuura Y. Structural basis for cell-cycle dependent nuclear import mediated by the karyopherin Kap121p. J Mol Biol. 2013 Mar 27. pii: S0022-2836(13)00194-0. doi:, 10.1016/j.jmb.2013.02.035. PMID:23541588 doi:http://dx.doi.org/10.1016/j.jmb.2013.02.035

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